Additional Genetic Variants in Inherited Dilated Cardiomyopathy

Genetic Testing for Dilated Cardiomyopathy

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Role of Genetic Factors in Dilated Cardiomyopathy

Genetic mutations and mechanisms in dilated cardiomyopathy.

Genetic mutations account for a significant percentage of cardiomyopathies, which are a leading cause of congestive heart failure. In hypertrophic cardiomyopathy (HCM), cardiac output is limited by the thickened myocardium through impaired filling and outflow. Mutations in the genes encoding the thick filament components myosin heavy chain and myosin binding protein C (MYH7 and MYBPC3) together...

Genetic polymorphisms in dilated cardiomyopathy Johann

Role of Genetic Factors in Dilated Cardiomyopathy

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by cardiac chamber enlargement and impaired systolic (and almost always diastolic) function. It is usually associated with heart failure, arrhythmias and/or conduction system disease and thromboembolic disease but may also be asymptomatic. DCM is diagnosed in the presence of left ventricular enlargement and systolic dysfunctio...